Before beginning your literature search, take some time to develop and refine your research question and plan the scope of your search.
This ensures that your search will effectively find the papers that you need, without missing important studies or wasting time on irrelevant articles.
Key steps at this stage
Step-by-step worksheet
You can fill out the Library's worksheet as you work your way through each step. The appendix includes real-world examples.
Background research can help:
Example: if your research topic relates to COPD therapies, during this step you might seek to answer general background questions such as:
How to conduct background research
Library catalogue
Start by searching for your topic in the Library catalogue. You can use a variety of sources, such as those listed below.
Clinical decision support tools
For clinical topics, check tools such as UpToDate, BMJ Best Practice, and the Australian Medicines Handbook. E.g. if you are researching a new therapy for COPD, try searching for COPD in UpToDate and viewing the guidance on diagnosis and staging, management etc.
Visit the Library website for a full list of clinical support tools and information on how to access them onsite and remotely.
Clinical Decision Support Tools
Tip: While viewing topics in UpToDate or BMJ Best Practice, check the references section for any relevant papers.
AI tools
Artificial intelligence (AI) tools can also help you quickly gain an overview of a topic and identify gaps in research. Visit Expand search and see the section on AI search tools for more information on how to use AI tools, along with a matrix of tools recommended by the Library.
Collect highly relevant articles
As you explore your research topic, it is useful to keep track of any highly relevant articles that you come across. These papers can be used in subsequent stages of the search process to:
Look out for these highly relevant papers while conducting background research. Such papers may also be recommended by subject matter experts, supervisors, or peers.
Tip: If you find a highly relevant paper, check its reference list for any additional relevant papers. Consider papers based on their relevance at this stage, rather than other factors such as when it was published.
The importance of an answerable question
Developing a clear and answerable research question makes it quicker and easier to find papers relevant to your topic. A clear question:
PICO question framework
The PICO acronym is widely used as a framework that helps to structure your clinical question and ensure that it is clear and answerable. PICO stands for Patient/Population, Intervention/Indicator, Comparison/Control, and Outcome.
When is PICO appropriate?
PICO is best suited to questions of clinical effectiveness, e.g. In Patient Group, is Therapy A more effective than Therapy B at treating Condition X?
If your research question has a different focus -- such as prevalence, risk, experiential data, or cost-effectivenes -- see the Other question frameworks section below for alternative frameworks for building your question.
Using PICO - with examples
To use PICO -- or an alternative question framework -- think carefully about your research topic and define each letter or concept. To start, define your 'P' by determining which specific patient group or population you are focusing on (e.g. adults 65+ with stable COPD), and so on. Be as specific and explicit as possible to create an effective PICO.
How to create PICO questions about diagnostic tests
PICO Variations
In PICOT, the 'T' is for a specified time period, e.g. "over 5 years" or "24 hours after surgery". It can also be a type of study -- e.g. qualitative study -- or test.
Here, the 'S' stands for study type or study design. Depending on your question, certain study types may be more appropriate clinical evidence than others. E.g. RCTs for therapy questions.
The 'C' is for context (or place), e.g. "the ED", "teaching hospitals", or "high-income countries".
If your research topic is not related to clinical effectiveness, it may be better suited to one of the question frameworks below instead of PICO.
Etiology and/or Risk | Prevalence or Incidence | Diagnostic Test Accuracy |
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PEO P = Population E = Exposure (independent variable) O = Outcome (dependent variable) |
CoCoPop Co = Condition Co = Context Pop = Population |
PIRD P = Population I = Index test R = Reference test D = Diagnosis of interest |
The below frameworks may be more suitable for questions relating to service improvement, cost-effectiveness, or similar.
ECLIPS E = Expectation |
CLIP C = Client |
Qualitative Research
These frameworks may be more appropriate for qualitative questions, such as those investigating experiences or perspectives.
PICo P = Population I = phenomenon of Interest Co = Context |
SPIDER S = Sample PI = Phenomenon of Interest D = Design E = Evaluation R = Research type |
SPICE S = Setting P = Perspective I = Intervention C = Comparison E = Evaluation |
For more information on alternative question frameworks including examples, visit the guide below from the University of London.
After developing a clear research question, consider whether your search will be more comprehensive or more targeted. Read on to learn more about the differences between each approach and the practical implications for your search process.
Comprehensive vs. targeted
Put very simply, these terms equate to the size of the 'net' that you use to 'catch' relevant literature during your search.
The more comprehensive your search, the bigger your net. The more targeted your search, the smaller your net.
For example:
Should your search be comprehensive or targeted?
This decision is usually based on the nature of your research and practical considerations such as time or resource constraints. Review the tables below for more information about when to use which approach. Tip: In some cases it may be easier to 'rule out' one approach as unsuitable.
Comprehensive search
Definition |
A comprehensive search that retrieves the maximum amount of relevant studies, but which requires additional time and resources for filtering and screening results. As comprehensiveness increases, so does the number of results. A highly comprehensive (or sensitive) search casts a wide net and therefore has lower precision. |
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Usage |
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Tips |
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Targeted search
Definition |
A targeted search that captures the most relevant studies, but does not necessarily locate every single piece of relevant literature. A very targeted (or precise) search risks missing relevant studies -- as it casts a small net -- but this approach is still suitable in many situations. |
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Usage |
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Tips |
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